Comments
yourfanat wrote: I am using another tool for Oracle developers - dbForge Studio for Oracle. This IDE has lots of usefull features, among them: oracle designer, code competion and formatter, query builder, debugger, profiler, erxport/import, reports and many others. The latest version supports Oracle 12C. More information here.
Cloud Expo on Google News
SYS-CON.TV

2008 West
DIAMOND SPONSOR:
Data Direct
SOA, WOA and Cloud Computing: The New Frontier for Data Services
PLATINUM SPONSORS:
Red Hat
The Opening of Virtualization
GOLD SPONSORS:
Appsense
User Environment Management – The Third Layer of the Desktop
Cordys
Cloud Computing for Business Agility
EMC
CMIS: A Multi-Vendor Proposal for a Service-Based Content Management Interoperability Standard
Freedom OSS
Practical SOA” Max Yankelevich
Intel
Architecting an Enterprise Service Router (ESR) – A Cost-Effective Way to Scale SOA Across the Enterprise
Sensedia
Return on Assests: Bringing Visibility to your SOA Strategy
Symantec
Managing Hybrid Endpoint Environments
VMWare
Game-Changing Technology for Enterprise Clouds and Applications
Click For 2008 West
Event Webcasts

2008 West
PLATINUM SPONSORS:
Appcelerator
Get ‘Rich’ Quick: Rapid Prototyping for RIA with ZERO Server Code
Keynote Systems
Designing for and Managing Performance in the New Frontier of Rich Internet Applications
GOLD SPONSORS:
ICEsoft
How Can AJAX Improve Homeland Security?
Isomorphic
Beyond Widgets: What a RIA Platform Should Offer
Oracle
REAs: Rich Enterprise Applications
Click For 2008 Event Webcasts
ALS Association-Funded Researchers Discover New Links Leading to Neuron Death

WASHINGTON, Dec. 10, 2012 /PRNewswire-USNewswire/ -- Researchers supported by The ALS Association have discovered an important process that puts neurons at risk of the cell death, which characterizes numerous neurodegenerative diseases. The discovery, which was published today in the Proceedings of the National Academy of Sciences, highlights the links between several proteins known to go awry in ALS and a related disease, frontotemporal dementia (FTD).

ALS is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Eventually, people with ALS lose the ability to initiate and control muscle movement, which often leads to total paralysis and death within two to five years of diagnosis. For unknown reasons, veterans are twice as likely to develop ALS as the general population. There is no cure, and only one drug approved by the U.S. Food and Drug Administration (FDA) modestly extends survival.

"This new finding puts together several critical links in the chain leading to neuronal death," said Lucie Bruijn, Ph.D., Chief Scientist for The ALS Association.

The first protein in the chain is called TDP-43. Lack of TDP-43 has previously been shown to cause both ALS and FTD. The new study showed that when there is too little TDP-43, another protein, called sortilin, is made in excess. Some copies of that protein are defective, the researchers found.

Both normal and defective sortilin bind to another protein, called progranulin, a growth factor for neurons. But when excess normal sortilin and the defective sortilin bind to progranulin, neurons become deprived of this important growth factor. Thus, too little TDP-43 leads to too much normal and defective sortilin, which diminishes the amount of neuroprotective progranulin. Lack of progranulin leads to death of neurons.

The research was led by Mercedes Prudencio, Ph.D., and Leonard Petrucelli, Ph.D., of the Mayo Clinic in Jacksonville, Florida, and Emanuele Buratti, Ph.D., of the International Center for Genetic Engineering and Biotechnology in Trieste, Italy.

Dr. Prudencio is a recipient of the Milton Safenowitz Post-Doctoral Fellowship for ALS Research from The ALS Association. The ALS Association is especially committed to bringing new concepts and methods into ALS research, and young scientists play an important role in this process. Funding is generously provided by the Safenowitz family through the Greater New York Chapter of The ALS Association, in memory of Milton, who died in 1998 of the disease.

"We are extremely pleased that our support has helped Dr. Prudencio advance the field through this research," Dr. Bruijn said. "The discovery of this mechanism is important for understanding how neurons die in ALS and FTD, and in the development of new therapies targeting this pathway."

About The ALS Association
The ALS Association is the only national non-profit organization fighting Lou Gehrig's Disease on every front.  By leading the way in global research, providing assistance for people with ALS through a nationwide network of chapters, coordinating multidisciplinary care through certified clinical care centers, and fostering government partnerships, The Association builds hope and enhances quality of life while aggressively searching for new treatments and a cure.  For more information about The ALS Association, visit our website at www.alsa.org.

SOURCE The ALS Association

About PR Newswire
Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest AJAXWorld RIA Stories
In his session at 21st Cloud Expo, Raju Shreewastava, founder of Big Data Trunk, provided a fun and simple way to introduce Machine Leaning to anyone and everyone. He solved a machine learning problem and demonstrated an easy way to be able to do machine learning without even cod...
The National Cyber Security Awareness Month is transitory, but many of the decisions we have made around the adoption of technology within our personal and business have brought with them risks that will stay with us for a while. A good example of this is the deployment and proli...
Companies are harnessing data in ways we once associated with science fiction. Analysts have access to a plethora of visualization and reporting tools, but considering the vast amount of data businesses collect and limitations of CPUs, end users are forced to design their structu...
22nd International Cloud Expo, taking place June 5-7, 2018, at the Javits Center in New York City, NY, and co-located with the 1st DXWorld Expo will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is no...
Bert Loomis was a visionary. This general session will highlight how Bert Loomis and people like him inspire us to build great things with small inventions. In their general session at 19th Cloud Expo, Harold Hannon, Architect at IBM Bluemix, and Michael O'Neill, Strategic Busin...
Subscribe to the World's Most Powerful Newsletters
Subscribe to Our Rss Feeds & Get Your SYS-CON News Live!
Click to Add our RSS Feeds to the Service of Your Choice:
Google Reader or Homepage Add to My Yahoo! Subscribe with Bloglines Subscribe in NewsGator Online
myFeedster Add to My AOL Subscribe in Rojo Add 'Hugg' to Newsburst from CNET News.com Kinja Digest View Additional SYS-CON Feeds
Publish Your Article! Please send it to editorial(at)sys-con.com!

Advertise on this site! Contact advertising(at)sys-con.com! 201 802-3021


SYS-CON Featured Whitepapers
ADS BY GOOGLE