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BioMosaics' Glypican-3 Antibody (clone 1G12) Validated at PhenoPath Laboratories for Immunohistochemical Detection of Liver Cancer

BURLINGTON, Vt. and SEATTLE, March 26 /PRNewswire/ -- BioMosaics Inc., a cancer biomarker development company, announced today that its monoclonal antibody product (clone 1G12) for detection of Glypican-3 (GPC3) has been validated for use as an immunohistochemical test for diagnosis of Hepatocellular Carcinoma (HCC) by PhenoPath Laboratories. PhenoPath Laboratories is a state-of-the-art reference pathology laboratory providing diagnostic immunohistochemistry (IHC), in situ hybridization (ISH), flow cytometry, and other molecular pathology services to pathologists throughout the United States.

"We are pleased that PhenoPath has added the 1G12 Glypican-3 antibody to its test menu. Immunohistochemistry using this antibody provides added specificity to the identification of HCC in patient tissue samples," said Dr. Mark Allegretta, BioMosaics Chief Scientific Officer. PhenoPath is CLIA-certified and accredited by the College of American Pathologists. In addition to testing performed at PhenoPath, the antibody is available in concentrated form (BioMosaics Catalog # B0055 and B0025), or as a ready-to-use, pre-diluted product for IHC (Catalog # B0134). Both formats are suitable for use with manual protocols or in automated immunostaining instruments.

The antibody validation studies were performed with formalin fixed paraffin embedded tissue sections used in routine immunohistochemistry tests. For validation, a series of tissues (normal & tumor) that would be part of the differential diagnosis in a clinical setting were tested to determine what percent might be positive. With the 1G12 antibody to GPC3, 88% (38/43) of cases with hepatocellular carcinoma showed strong positive immunostaining. In all observed cases, non-neoplastic liver that was present in the specimen was negative or showed rare cells positive for Glypican-3. All 21 cases of nodules in cirrhotic liver were negative for Glypican-3.

Primary Liver Cancer, or Hepatocellular Carcinoma, is one of the most common and aggressive malignant tumors worldwide, causing an estimated one million deaths annually. The main causative agents are hepatitis B virus (HBV), hepatitis C virus (HCV), as well as alcoholic cirrhosis and non-alcoholic steatohepatitis (NASH) which is associated with obesity and diabetes. The incidence of HCC has been steadily increasing over the past ten years and is expected to continue to rise over the next decade.

Glypican-3, an oncofetal antigen, is a member of the glypican family of GPI-anchored cell-surface heparan sulfate proteoglycans. Many studies have shown that, using the 1G12 antibody, GPC3 is detected at the protein level by immunohistochemistry in most cases of primary liver cancer, including small tumors. It is undetectable in normal liver and benign hepatic lesions. Glypican-3 has been identified as one of the earliest proteins detected in HCC. Recent validation studies using BioMosaics GPC3 1G12 monoclonal antibody have confirmed the early presence of GPC3 on HCC biopsies and in a percentage of highly dysplastic cirrhotic nodules. This class of dysplastic nodule is considered to be an early form of HCC, and immunohistochemical studies show that they are routinely negative for alpha fetoprotein. Glypican-3 therefore has considerable promise as a biomarker for early detection of HCC.

About BioMosaics

BioMosaics is a biotechnology company located in Burlington VT engaged in the development and commercialization of innovative products for the early diagnosis, prediction, and monitoring of cancer. http://www.biomosaics.com

About PhenoPath Laboratories

PhenoPath Laboratories is a physician-owned pathology reference laboratory providing diagnostic and contract research services to hospitals, physician offices, surgery centers, biopharmaceutical companies and research institutions nationwide. http://www.phenopath.com

    Contacts:
    BioMosaics Inc.
    Mark Allegretta PhD; m.allegretta@biomosaics.com

Note: Statements in this news release that are not historical facts are "forward-looking statements" within the meaning given to that term in the Private Securities Litigation Reform Act of 1995. The Company intends that such forward-looking statements be subject to the safe harbors created thereby. Since these statements involve risks and uncertainties and are subject to change at any time, the Company's actual results could differ materially from expected results.

SOURCE BioMosaics Inc.

About PR Newswire
Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

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